Benzyl Alcohol → HCID 69156334, compound

Participants

Reaction Steps

To a mixture of 2-(benzo[1,3]dioxol-5-ylmethyl)-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (220 mg), triethylamine (91 μl) and toluene (4.4 ml) was added diphenylphosphorylazide (185 μl) at room temperature with stirring, and the mixture was stirred at room temperature for 1 hr. and at 80° C. for 1 hr. After cooling, benzyl alcohol (79 μl) was added to the reaction mixture, and the mixture was further stirred at 80° C. for 12 hrs. After cooling the reaction mixture, the solvent was evaporated under reduced pressure and the residue was purified by medium pressure preparative LC (hexane/ethyl acetate=4/1-1/1) to give the title compound (160 mg) as pale-yellow crystals.

Provenance & Evidence