4-Methoxybenzyl bromide → HCID 23060642, compound

HRID 750215Notes

Reaction equation

HRID 750215 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[C:20]([CH2:21][OH:22])=[C:19]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([Br:29])[CH:17]=4)[C:12]3=[O:30])=[CH:9][C:4]=2[O:3][CH2:2]1.[CH3:31][O:32][C:33]1[CH:40]=[CH:39][C:36]([CH2:37]Br)=[CH:35][CH:34]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[C:20]([CH2:21][O:22][CH2:37][C:36]4[CH:39]=[CH:40][C:33]([O:32][CH3:31])=[CH:34][CH:35]=4)=[C:19]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([Br:29])[CH:17]=4)[C:12]3=[O:30])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 1650214-Methoxybenzyl bromideHCID 23060976HCID 23060976, compound

Product 1

HCID 23060642HCID 23060642, compound

Procedure

The present compound was synthesized by a method similar to that in Example 240 and using 2-(benzo[1,3]dioxol-5-ylmethyl)-6-bromo-3-hydroxymethyl-4-phenyl-2H-isoquinolin-1-one (250 mg) and 4-methoxybenzylbromide. Colorless crystals (240 mg).

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 240

Sources & evidence

ORD record
ord-ab87fa28d5eb4b6da22dfddd7ac258c0
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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