Methanol → HCID 69156811, compound

Participants

Reaction Steps

A mixture of 3-[2-(benzo[1,3]dioxol-5-ylmethyl)-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]acrylic acid methyl ester (100 mg), Raney-nickel (suitable amount), methanol (2.0 ml) and THF (2.0 ml) was stirred at room temperature under a hydrogen atmosphere for 3 hrs. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by medium pressure preparative LC (hexane/ethyl acetate=9/1-1/1) to give the title compound (55 mg) as a colorless powder.

Provenance & Evidence