Chloromethyl Methyl Ether → HCID 69155538, compound

Participants

Reaction Steps

To a mixture of 6-bromo-2-(4-hydroxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (200 mg), potassium carbonate (89 mg) and DMF (4.0 ml) was added methoxymethylchloride (39 μl) at room temperature with stirring, and the mixture was stirred at 50° C. for 12 hrs. After cooling the reaction mixture, the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and water, and the organic layer was dried over magnesium sulfate and concentrated. The residue was purified by medium pressure preparative LC (hexane/ethyl acetate=9/1-1/1) to give the title compound (75 mg) as colorless crystals.

Provenance & Evidence