Bromine → HCID 69155771, compound

Participants

Reaction Steps

To a mixture of 6-bromo-2-(4-hydroxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (290 mg), aluminum chloride (82 mg) and dichloromethane (5.7 ml) was added bromine (39 μl) at 0° C. with stirring, and the mixture was stirred for 1 hr. After the completion of the reaction, the reaction mixture was washed with water, dried and concentrated. The residue was purified by medium pressure preparative LC (hexane/ethyl acetate=4/1-1/1) to give the title compound (180 mg) as colorless crystals.

Provenance & Evidence