HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Methoxyphenyl)boronic acid → 2-benzyl-6-chloro-4-(4-methoxyphenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Methoxyphenyl)boronic acid | HCID 201262 | — |
| Reactant | 2-Benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester | HCID 86599557 | — |
| Product | 2-benzyl-6-chloro-4-(4-methoxyphenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester | HCID 69156859 | — |
Reaction Steps
The present compound was synthesized by a method similar to that in Example 272 and using 2-benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (100 mg) and 4-methoxyphenylboronic acid. beige powder (61 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-4de48490930d43b9ad9b04fd13115f11 |
| Source note | uspto-grants-2008_07 |