2,4-Difluorophenylboronic acid → HCID 69157343, compound

HRID 750242Notes

Reaction equation

HRID 750242 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:7](=[O:24])[C:8]2[C:13]([C:14]=1OS(C(F)(F)F)(=O)=O)=[CH:12][C:11]([Cl:23])=[CH:10][CH:9]=2)=[O:4].[F:32][C:33]1[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:34]=1B(O)O>>[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:7](=[O:24])[C:8]2[C:13]([C:14]=1[C:36]1[CH:35]=[CH:34][C:33]([F:32])=[CH:38][C:37]=1[F:39])=[CH:12][C:11]([Cl:23])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 27343342,4-Difluorophenylboronic acidHCID 865995572-Benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester

Product 1

HCID 69157343HCID 69157343, compound

Procedure

The present compound was synthesized by a method similar to that in Example 272 and using 2-benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (100 mg) and 2,4-difluorophenylboronic acid. A colorless powder (9 mg).

Workup

  1. customThe present compound was synthesized by a method similar to that in Example 272

Sources & evidence

ORD record
ord-dfa9dd8294d54c6f875c277dff47df46
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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