HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Methanesulfonyl)phenylboronic acid → 2-benzyl-6-chloro-4-(4-methanesulfonylphenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Methanesulfonyl)phenylboronic acid | HCID 2734364 | — |
| Reactant | 2-Benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester | HCID 86599557 | — |
| Product | 2-benzyl-6-chloro-4-(4-methanesulfonylphenyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester | HCID 69157131 | — |
Reaction Steps
The present compound was synthesized by a method similar to that in Example 272 and using 2-benzyl-6-chloro-1-oxo-4-trifluoromethanesulfonyloxy-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (100 mg) and 4-(methanesulfonyl)phenylboronic acid. A colorless powder (63 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-a8b382b065e6424e9a2d91e3c2a5859e |
| Source note | uspto-grants-2008_07 |