反应详情

To a 4N-hydrochloric acid ethyl acetate solution (4 ml) was added 2-(4-tert-butoxycarbonylbenzyl)-6-dimethylcarbamoyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (140 mg), and the mixture was stirred at room temperature for 4 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained residue was crystallized from methanol-diisopropyl ether to give the title compound (86 mg).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe obtained residue was crystallized from methanol-diisopropyl ether