HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylether ethyl acetate → 6-chloro-3-(1-hydroxypentyl)-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylether ethyl acetate | HCID 22281796 | — |
| Reactant | 6-Chloro-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbaldehyde | HCID 23060611 | — |
| Reactant | HCID 178418265 | HCID 178418265 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-chloro-3-(1-hydroxypentyl)-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-one | HCID 23060573 | — |
Reaction Steps
In the same manner as in Example 313, the title compound was synthesized using 6-chloro-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbaldehyde and a solution (2M) of n-butylmagnesium chloride in THF. Crystals (ethyl acetate-diisopropyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-ba7b8795b94846bcbdb404ebd2e2f897 |
| Source note | uspto-grants-2008_07 |