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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 750278Generated: October 27, 2026

THF diisopropyl ether → 6-chloro-2-(4-methanesulfonylbenzyl)-4-phenyl-3-propionyl-2H-isoquinolin-1-one

https://huagongshe.com/reaction/750278

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTHF diisopropyl etherHCID 21940044—
Reactant6-chloro-3-(1-hydroxypropyl)-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-oneHCID 23060666—
Product6-chloro-2-(4-methanesulfonylbenzyl)-4-phenyl-3-propionyl-2H-isoquinolin-1-oneHCID 44451693—

Reaction Steps

In the same manner as in Example 311, the title compound was synthesized using 6-chloro-3-(1-hydroxypropyl)-2-(4-methanesulfonylbenzyl)-4-phenyl-2H-isoquinolin-1-one. Crystals (THF-diisopropyl ether).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07402595B2
Source datasetuspto-grants-2008_07
ORD IDord-81957be213f5432baf78c023a946da79
Source noteuspto-grants-2008_07