Monomethyl terephthalate → HCID 69157125, compound

Participants

Reaction Steps

To a solution of 2-(4-aminobenzyl)-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (139 mg) in dichloromethane (5 ml) were added terephthalic acid monomethyl ester (65 mg), 1-hydroxy-1H-benzotriazole (64 mg) and dimethylpyridin-4-yl-amine (51 mg), and then 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (103 mg) was added at room temperature. The mixture was stirred at room temperature for 15 hrs. Dichloromethane was added, and the mixture was washed with 1N hydrochloric acid and saturated brine and dried by adding sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by silica gel column chromatography (ethyl acetate/methanol=1/0-+9/1) to give the title compound (103 mg, 55%).

Provenance & Evidence