Hydrogen chloride-ethyl acetate → HCID 69155690, compound

HRID 750305Notes

Reaction equation

HRID 750305 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]([NH:32][NH:33]C(OC(C)(C)C)=O)=[O:31])=[CH:26][CH:25]=2)[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([Br:21])=[CH:10][CH:9]=2)=[O:4].C(OC(=O)C)C.[ClH:47]>>[ClH:47].[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:30]([NH:32][NH2:33])=[O:31])=[CH:28][CH:29]=2)[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:12][C:11]([Br:21])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69157432HCID 69157432, compound

Product 1

HCID 69155690HCID 69155690, compoundYield 79%

Procedure

To 6-bromo-2-[4-(N′-tert-butoxycarbonylhydrazinocarbonyl)benzyl]-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (158 mg) was added a solution (5 ml) of 4N hydrochloric acid ethyl acetate at room temperature and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure and the obtained residue was crystallized from diisopropyl ether to give the title compound (112 mg, 79%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained residue was crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-23be8b9f13e845afbe182fe0830c3e9d
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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