Methanol → HCID 69157458, compound

Participants

Reaction Steps

To a mixture of 6-bromo-2-[4-(4-ethoxycarbonylpiperidine-1-carbonyl)benzyl]-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (290 mg), methanol (5 ml) and tetrahydrofuran (5 ml) was added a solution (0.1 ml) of 8N aqueous sodium hydroxide and the mixture was stirred at room temperature for 12 hrs. The solvent was evaporated under reduced pressure, water was added and the mixture was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine and dried by adding sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by preparative liquid chromatography to give the title compound (72 mg, 26%).

Provenance & Evidence