4-(Chlorosulfonyl)benzoic acid → HCID 69155974, compound

HRID 750314Notes

Reaction equation

HRID 750314 reaction equation
[C:1]([C:4]1[N:5]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=2)[C:6](=[O:21])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][C:10]([Br:20])=[CH:9][CH:8]=2)(=[O:3])[CH3:2].[C:30]([C:33]1[CH:38]=[CH:37][C:36]([S:39](Cl)(=[O:41])=[O:40])=[CH:35][CH:34]=1)([OH:32])=[O:31]>>[C:1]([C:4]1[N:5]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([NH:29][S:39]([C:36]3[CH:35]=[CH:34][C:33]([C:30]([OH:32])=[O:31])=[CH:38][CH:37]=3)(=[O:41])=[O:40])=[CH:27][CH:28]=2)[C:6](=[O:21])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][C:10]([Br:20])=[CH:9][CH:8]=2)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 823854-(Chlorosulfonyl)benzoic acidHCID 23060586HCID 23060586, compound

Product 1

HCID 69155974HCID 69155974, compound

Procedure

In the same manner as in Example 377, 3-acetyl-2-(4-aminobenzyl)-6-bromo-4-phenyl-2H-isoquinolin-1-one was reacted with 4-carboxybenzenesulfonyl chloride to give the title compound. yield: 45 mg (26%)

Sources & evidence

ORD record
ord-9a5e0150db234b099fdeae2d83d8d6fd
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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