HuagongsheHuagongshe Chemistry Print Report · For research reference only
Mafenide Hydrochloride → 6-bromo-1-oxo-4-phenyl-2-(4-sulfamoylbenzyl)-1,2-dihydroisoquinoline-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Mafenide Hydrochloride | HCID 67313 | — |
| Reactant | 6-Bromo-4-phenyl-3-isocoumarincarboxylic acid | HCID 23060777 | — |
| Product | 6-bromo-1-oxo-4-phenyl-2-(4-sulfamoylbenzyl)-1,2-dihydroisoquinoline-3-carboxylic Acid | HCID 23060824 | 71% |
Reaction Steps
The title compound (3.64 g, 71%) was synthesized by a method similar to that in Example 331 and using 6-bromo-1-oxo-4-phenyl-1H-isochromen-3-carboxylic acid and 4-sulfamoylbenzylamine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402595B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-f36f6eac03fa414c899a8047cfb26c6f |
| Source note | uspto-grants-2008_07 |