3-Fluorobenzylamine → 3-acetyl-6-bromo-2-(3-fluorobenzyl)-4-phenyl-2H-isoquinolin-1-one

HRID 750322Notes

Reaction equation

HRID 750322 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].[C:10]([C:13]1[O:14][C:15](=O)[C:16]2[C:21]([C:22]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[CH:20][C:19]([Br:29])=[CH:18][CH:17]=2)(=[O:12])[CH3:11]>>[C:10]([C:13]1[N:6]([CH2:5][C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=2)[C:15](=[O:14])[C:16]2[C:21]([C:22]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[CH:20][C:19]([Br:29])=[CH:18][CH:17]=2)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 668533-FluorobenzylamineHCID 230605293-Acetyl-6-bromo-4-phenylisochromen-1-one

Product 1

HCID 230606123-acetyl-6-bromo-2-(3-fluorobenzyl)-4-phenyl-2H-isoquinolin-1-one

Procedure

In the same manner as in Example 411, the title compound was synthesized from 3-fluorobenzylamine and 3-acetyl-6-bromo-4-phenylisochromen-1-one.

Sources & evidence

ORD record
ord-4b14379c7e394d2db7370bcd6d8d702a
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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