2-Benzoyl-4-chlorobenzoic acid → 4-(6-chloro-1-oxo-4-phenyl-3-butyryl-1H-isoquinolin-2-ylmethyl)benzoic Acid Methyl Ester

HRID 750339Notes

Reaction equation

HRID 750339 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:19])[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][CH2:13][CH:14]([OH:18])[CH2:15][CH2:16][CH3:17])=[CH:7][CH:6]=1.[C:20]([C:28]1[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:29]=1[C:30](O)=[O:31])(=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:2][O:3][C:4](=[O:19])[C:5]1[CH:6]=[CH:7][C:8]([CH2:11][N:12]2[C:13]([C:14](=[O:18])[CH2:15][CH2:16][CH3:17])=[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:28]3[C:29](=[CH:33][CH:34]=[C:35]([Cl:37])[CH:36]=3)[C:30]2=[O:31])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 122052902-Benzoyl-4-chlorobenzoic acidHCID 69156613HCID 69156613, compound

Product 1

HCID 691558004-(6-chloro-1-oxo-4-phenyl-3-butyryl-1H-isoquinolin-2-ylmethyl)benzoic Acid Methyl Ester

Procedure

In the same manner as in Example 458, Step 2, the title compound was synthesized from 4-[(2-hydroxypentylamino)methyl]benzoic acid methyl ester hydrochloride and 2-benzoyl-4-chlorobenzoic acid.

Sources & evidence

ORD record
ord-52f8d285a5d04ca8951b905745537ab9
Source dataset
uspto-grants-2008_07
Patent number
US07402595B2

Reaction notes

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