Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Azido(trimethyl)stannane | HCID 5104973 | — |
| Reactant | HCID 69155855 | HCID 69155855 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178458124 | HCID 178458124 | 58% |
Reaction Steps
To a suspension of 4-(6-bromo-1-oxo-4-phenyl-3-propionyl-1H-isoquinolin-2-ylmethyl)benzonitrile (1.89 g) in toluene (80 ml) was added trimethyltin azide (2.47 g) and the mixture was stirred at 110° C. for 4 days. Water (50 ml) and methanol (50 ml) were added at room temperature, and the precipitated crystals were collected by filtration to give the title compound (1.19 g, 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07402595B2 |
|---|
| Source dataset | uspto-grants-2008_07 |
|---|
| ORD ID | ord-ca5f811658c54cf4a3234d3be272a0e7 |
|---|
| Source note | uspto-grants-2008_07 |
|---|
