Methanol → HCID 69156333, compound

Participants

Reaction Steps

To a solution of 4-[(3-acetyl-6-chloro-1-oxo-4-phenyl-1H-isoquinolin-2-yl)methyl]benzoic acid methyl ester (1.5 g) in THF (15 ml) were added methanol (15 ml) and 8N-aqueous sodium hydroxide solution (0.8 ml) at room temperature, and the mixture was stirred for 12 hrs. The reaction mixture was concentrated under reduced pressure, water and 10% hydrochloric acid were added to the residue. The aqueous layer was acidified and extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by recrystallization (ethyl acetate-hexane) to give the title compound (1.2 g).

Provenance & Evidence