Bromomethyl acetate → HCID 69156945, compound

HRID 750376Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([CH3:22])=O)=[CH:16][CH:15]=1)[C:6]([C:23](=[O:26])[CH2:24][CH3:25])=[C:5]2[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.BrC[O:35][C:36](=[O:38])[CH3:37]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20][CH2:22][O:38][C:36](=[O:35])[CH3:37])=[CH:16][CH:15]=1)[C:6]([C:23](=[O:26])[CH2:24][CH3:25])=[C:5]2[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

Reactant 2

HCID 68536Bromomethyl acetate

HCID 23060791HCID 23060791, compound

Product 1

HCID 69156945HCID 69156945, compoundYield 69%

Procedure

In the same manner as in Example 552, the title compound (190 mg, 69%) was obtained from 6-bromo-2-(4-methanesulfinylbenzyl)-4-phenyl-3-propionyl-2H-isoquinolin-1-one and acetic acid bromomethyl ester.

Sources & evidence

ORD record: ord-326465a4290748ea868ef07e497acd99
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07402595B2

Reaction notes

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