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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 750429Generated: October 31, 2026

Methanol → Methyl indoline-2-carboxylate

https://huagongshe.com/reaction/750429

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantThionyl ChlorideHCID 24386—
ReactantIndoline-2-carboxylic acidHCID 86074—
ProductMethyl indoline-2-carboxylateHCID 2794655—

Reaction Steps

Racemic indoline-2-carboxylic acid, as a starting material of Reaction Scheme 1, is dissolved in methanol and then the reaction is conducted under the slow addition of thionyl chloride to obtain racemic indoline-2-carboxylic acid methyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07405070B2
Source datasetuspto-grants-2008_07
ORD IDord-2d6db8ccbb6341e7b831a7cb95f1a027
Source noteuspto-grants-2008_07