HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetylmorpholine → 2-(4-morpholinyl)-8-phenoxy-4H-1-benzopyran-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetylmorpholine | HCID 15543 | — |
| Reactant | Trifluoromethanesulfonic anhydride | HCID 67749 | — |
| Reactant | Methyl 3-phenoxy-2-hydroxybenzoate | HCID 22263553 | — |
| Product | 2-(4-morpholinyl)-8-phenoxy-4H-1-benzopyran-4-one | HCID 9880248 | 27.8% |
Reaction Steps
Condensation of the lithium enolate of N-acetyl morpholine (0.21 g, 1.6 mmol) with methyl 3-phenoxy-2-hydroxybenzoate (0.25 g, 1.0 mmol) followed by cyclodehydration with trifluoromethanesulfonic anhydride (0.60 ml, 3.6 mmol) as described above yielded TGX-134 as an off-white solid (0.090 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405211B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-8c03aa44a2974e7888ebca03c4e0997d |
| Source note | uspto-grants-2008_07 |