1,1-Dimethylethyl 2-(2-hydroxyethyl)-4-(phenylmethyl)-1-piperazinecarboxylate → tert-Butyl 2-(2-hydroxyethyl)piperazine-1-carboxylate

Participants

Reaction Steps

A solution of (RS)-4-benzyl-1-(tert-butyloxycarbonyl)-2-(2-hydroxyethyl)piperazine (D5) (2.5 g, 7.81 mmol) in ethanol (150 ml) was hydrogenated at atmospheric pressure and room temperature in the presence of 10% palladium on charcoal (2.07 g, 54% paste with water) for 3.5 h. The mixture was filtered through Kieselguhr and the filtrate evaporated in vacuo to give the title compound as a colourless oil (1.65 g, 92%). Mass spectrum (AP+): Found 231 (MH+). C11H22N2O3 requires 230.

Provenance & Evidence