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3-chloro-4-fluoro-N-(5-nitropyrimidin-2-yl)benzamide → N-(5-aminopyrimidin-2-yl)-3-chloro-4-fluorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-chloro-4-fluoro-N-(5-nitropyrimidin-2-yl)benzamide | HCID 57447263 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-(5-aminopyrimidin-2-yl)-3-chloro-4-fluorobenzamide | HCID 21114550 | 80% |
反応手順
To 1C (1.16 g, 3.92 mmol) in a mixture of 60 mL EtOH and 10 mL MeOH was added 10% Pt/C (300 mg). The reaction was stirred under 1 atmosphere of hydrogen for 1.5 h, filtered, and concentrated to give 850 mg (80% yield) ID. RP HPLC ret. t.: 1.58 min. and (M+H)+: 267.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07405213B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-0452766825dd4b97a1d8aba4b845e575 |
| 出典メモ | uspto-grants-2008_07 |