Sodium Bicarbonate → HCID 178491840, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 6-chloro-3-(2,3-difluoro-6-methoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidine (Example 3, 148 mg, 0.50 mmol) in DMF (2.5 mL), sodium bicarbonate (100 mg) and 1-methanesulfonyl-piperidin-4-ylamine, 125 mg, 0.70 mmol) were added and the mixture was stirred at 100° C. for 4 hours. The solvent was removed under reduced pressure and the residue was treated with water. The solid was filtered and dried. Recrystallization from 2% MeOH/CH2Cl2 gave 92 mg off-white solid. 42%. MS (M+H)+, 439.

Provenance & Evidence