HCID 59753864, compound → HCID 178491798, compound

HRID 750489Notes

Reaction equation

HRID 750489 reaction equation
Cl[C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:12]=3[O:18][CH3:19])[C:5]2=[CH:4][N:3]=1.[NH2:20][C@H:21]1[CH2:26][CH2:25][N:24]([S:27]([CH3:30])(=[O:29])=[O:28])[CH2:23][C@@H:22]1O>>[F:17][C:15]1[CH:14]=[CH:13][C:12]([O:18][CH3:19])=[C:11]([C:10]2[C:5]3[C:6](=[N:7][C:2]([NH:20][CH:21]4[CH2:26][CH2:25][N:24]([S:27]([CH3:30])(=[O:29])=[O:28])[CH2:23][CH2:22]4)=[N:3][CH:4]=3)[NH:8][N:9]=2)[CH:16]=1

Participants

3

Reactant 2

HCID 59753864HCID 59753864, compoundHCID 178491797HCID 178491797, compound

Product 1

HCID 178491798HCID 178491798, compound

Procedure

The same procedure as described in Example 25 was used starting from 6-chloro-3-(5-fluoro-2-methoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidine, Example 24, (103 mg, 0.37 mmol), and (3S,4S)-4-amino-1-methanesulfonyl-piperidin-3-ol, (115 mg, 0.59 mmol), to give a yellow solid. 70 mg, 46%. MS (M+H)+, 437.

Workup

  1. customto give a yellow solid

Sources & evidence

ORD record
ord-ed641014dcb0466fb7f698c14252d9d8
Source dataset
uspto-grants-2008_07
Patent number
US07405220B2

Reaction notes

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