[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 178504946, compound

HRID 750492Notes

Reaction equation

HRID 750492 reaction equation
Cl[C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=3)[C:5]2=[CH:4][N:3]=1.FC(F)(F)C(O)=O.[CH3:25][S:26]([N:29]1[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]1)(=[O:28])=[O:27]>>[F:17][C:13]1[CH:12]=[C:11]([C:10]2[C:5]3[C:6](=[N:7][C:2]([NH:35][CH:32]4[CH2:33][CH2:34][N:29]([S:26]([CH3:25])(=[O:28])=[O:27])[CH2:30][CH2:31]4)=[N:3][CH:4]=3)[NH:8][N:9]=2)[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 178505662HCID 178505662, compound

Product 1

HCID 178504946HCID 178504946, compoundYield 6%

Procedure

The compound was prepared from 6-chloro-3-(3-fluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidine (Example 9) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoro-acetic acid in an analogous manner as described in Example 4 and was purified by HPLC (Gilson) to give a free base (6% yield). MS (M+H)+, 391.25.

Workup

  1. customwas purified by HPLC (Gilson)

Sources & evidence

ORD record
ord-d11723bef48849b6a4b5a5092e853674
Source dataset
uspto-grants-2008_07
Patent number
US07405220B2

Reaction notes

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