4-Fluoroaniline → [3-(2,6-Difluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(4-fluoro-phenyl)-amine

Participants

Role	Name	HCID	Charge
Reactant	4-Fluoroaniline	HCID 9731	—
Reactant	HCID 178505726	HCID 178505726	—
Product	[3-(2,6-Difluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(4-fluoro-phenyl)-amine	HCID 178505861	59%

Reaction Steps

The compound was prepared from 6-chloro-3-(2,6-difluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidine (Example 12) and 4-fluoroaniline (Aldrich) in an analogous manner as described in Example 32 (160° C.). Filtration and washing with 2-propanol after the reaction gave the title product (59%). MS (M+H)+, 342.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07405220B2
Source dataset	uspto-grants-2008_07
ORD ID	ord-e734e4c5aaa0438db3cb62c5a4a39ab1
Source note	uspto-grants-2008_07