Aniline → HCID 178489417, compound

HRID 750495Notes

Reaction equation

HRID 750495 reaction equation
Cl[C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[O:17][CH3:18])[C:5]2=[CH:4][N:3]=1.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:18][O:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:10]1[C:5]2[C:6](=[N:7][C:2]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:3][CH:4]=2)[NH:8][N:9]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 178489416HCID 178489416, compound

Product 1

HCID 178489417HCID 178489417, compoundYield 69%

Procedure

The compound was prepared from 6-chloro-3-(2-methoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidine (Example 6) and aniline (Aldrich) in an analogous manner as described in Example 32 (175° C.) and the title compound was obtained in 69% yield. MS (M+H)+, 318.2.

Workup

  1. customas described in Example 32 (175° C.)

Sources & evidence

ORD record
ord-496a63cc46624bfdbb900a10c071dfb9
Source dataset
uspto-grants-2008_07
Patent number
US07405220B2

Reaction notes

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