benzyl ((1S,3R)-3-(pyrazin-2-ylamino)cyclohexyl)carbamate → (1R,3S)-N1-(pyrazin-2-yl)cyclohexane-1,3-diamine

Participants

Reaction Steps

To a solution of benzyl N-[(1S,3R)-3-(pyrazin-2-ylamino)cyclohexyl]carbamate, 74a, (0.040 g, 0.123 mmol) in methanol (10 mL) was added 10% Pd/C (0.043 g, 0.040 mmol) and the resulting suspension was stirred under an atmosphere of hydrogen for three hours until LCMS indicated completion of the reaction. The solution was filtered through a bed of celite and concentrated in vacuo to give a yellow solid, which was used without further purification.

Provenance & Evidence