2-Chloro-5-fluorotoluene → (5-Chloro-2-fluoro-4-methylphenyl)methanol

HRID 750576Notes

Reaction equation

HRID 750576 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5](F)=[CH:4][C:3]=1[CH2:10][OH:11].[Cl:12]C1C=CC(F)=CC=1C>>[Cl:12][C:5]1[C:6]([CH3:8])=[CH:7][C:2]([F:1])=[C:3]([CH2:10][OH:11])[CH:4]=1

Participants

3

Reactant 2

HCID 1184752-Chloro-5-fluorotolueneHCID 18550538(2,5-Difluoro-4-methylphenyl)methanol

Product 1

HCID 18550823(5-Chloro-2-fluoro-4-methylphenyl)methanol

Procedure

(5-Chloro-2-fluoro-4-methyl-phenyl)-methanol was prepared in analogous fashion to (2,5-difluoro-4-methyl-phenyl)-methanol using 2-chloro-5-fluorotoluene as starting material. 1H NMR (400 MHz, CDCl3) δ 7.38 (d, 1H, J=6.8 Hz), 6.92 (d, 1H, J=10 Hz), 4.69 (s, 2H), 2.34 (s, 3H) ppm.

Sources & evidence

ORD record
ord-24da2f70931c4392b9b13c897589baf3
Source dataset
uspto-grants-2008_07
Patent number
US07405218B2

Reaction notes

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