HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester → 3-(2,6-Difluoro-4-methyl-benzyloxy)-5-[3-(3-hydroxy-5-pyrrolidin-1-yl-pentyl)-ureido]-isothiazole-4-carboxylic Acid Amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester | HCID 11384589 | — |
| Reactant | 1-Amino-5-(pyrrolidin-1-yl)pentan-3-ol | HCID 18550322 | — |
| Product | 3-(2,6-Difluoro-4-methyl-benzyloxy)-5-[3-(3-hydroxy-5-pyrrolidin-1-yl-pentyl)-ureido]-isothiazole-4-carboxylic Acid Amide | HCID 10255312 | — |
Reaction Steps
The title compound was prepared from [4-carbamoyl-3-(2,6-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and 1-amino-5-pyrrolidin-1-yl-pentan-3-ol by the procedure analogous to Example 1. MS (APCl, m/z): 498 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405218B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-dfc970fae5944436a11fc53f816792b1 |
| Source note | uspto-grants-2008_07 |