Methyl iodide → HCID 59753845, compound

HRID 750637Notes

Reaction equation

HRID 750637 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[S:13](=[O:21])(=[O:20])[NH:12][N:11]=2)=[CH:2]1.[CH3:22]I.Br[CH2:25][C:26]([O:28]C(C)(C)C)=[O:27]>>[CH3:22][N:12]1[N:11]=[C:10]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:1]([CH2:25][C:26]([OH:28])=[O:27])[CH:2]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[S:13]1(=[O:21])=[O:20]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 79177tert-Butyl bromoacetateHCID 136388609HCID 136388609, compound

Product 1

HCID 59753845HCID 59753845, compound

Procedure

The product of Example 17, step c) was alkylated with methyl iodide and t-butyl bromoacetate following the procedure described in example 17, step d). 1H NMR (DMSO-d6) δ 8.11-7.90 (m, 5H), 7.85 (s, 1H), 7.44 (d, J=8.1 Hz, 1H), 7.22 (dt, J=0.9, 7.5 Hz, 1H), 7.15 (dt, J=1.2, 7.5 Hz, 1H), 4.72 (s, 2H), 3.51 (s, 3H); MS: ESI (negative): 368 (M−H).

Sources & evidence

ORD record
ord-af9f0c8fbf6d4829b5521fbe71952124
Source dataset
uspto-grants-2008_07
Patent number
US07405215B2

Reaction notes

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