2-(Chloromethyl)benzothiazole → [3-(3-Benzothiazol-2-ylmethyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-5-chloro-2-methyl-indol-1-yl]-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	2-(Chloromethyl)benzothiazole	HCID 304978	—
Reactant	tert-butyl 2-(5-chloro-3-(4-hydroxyphthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetate	HCID 58247168	—
Product	[3-(3-Benzothiazol-2-ylmethyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-5-chloro-2-methyl-indol-1-yl]-acetic acid	HCID 11540839	—

Reaction Steps

The title compound was prepared from the product of example 16, step c) and 2-chloromethyl-benzothiazole using the procedure described in example 14. 1H NMR (DMSO-d6) δ 8.44-8.41 (m, 1H), 8.08 (d, J=8.1 Hz, 1H), 7.99 (d, J=8.1 Hz, 1H), 7.96-7.92 (m, 2H), 7.50 (t, J=7.5 Hz, 1H), 7.44 (t, J=7.5 Hz, 1H), 7.24 (d, J=1.8 Hz, 1H), 7.15 (dd, J=8.7, 2.1 Hz, 1H), 5.86 (s, 2H), 5.12 (s, 2H), 2.28 (s, 3H); MS: ESI (negative): 513, 515 (M−H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07405215B2
Source dataset	uspto-grants-2008_07
ORD ID	ord-1fe12be776cf4eb38a7120e1964dfa3a
Source note	uspto-grants-2008_07