HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoethanol → rac-{3-[2-(2-Hydroxy-ethyl)-1,1-dioxo-2,3-dihydro-1H-1lambda*6*-benzo[d]isothiazol-3-yl]-2-methyl-indol-1-yl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | [3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-2-methyl-indol-1-yl]-acetic acid tert-butyl ester | HCID 67317115 | — |
| Product | rac-{3-[2-(2-Hydroxy-ethyl)-1,1-dioxo-2,3-dihydro-1H-1lambda*6*-benzo[d]isothiazol-3-yl]-2-methyl-indol-1-yl}-acetic acid | HCID 46890209 | — |
Reaction Steps
The title compound was prepared by the method described for example 14 using the product from example 3, step c) and 2-bromoethanol. 1H NMR (DMSO-d6) δ 7.98-7.95 (m, 1H), 7.62-7.58 (m, 3H), 7.36 (d, J=8.4 Hz, 1H), 7.04-7.01 (m, 2H), 6.80-6.78 (m, 1H), 6.14 (s, 1H), 5.00 (s, 2H), 4.75 (bs, 1H), 3.59-3.53 (m, 1H), 3.26-3.17 (m, 2H), 3.02-2.92 (m, 1H), 2.39 (s, 3H); MS: ESI (negative): 399 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405215B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-82d2d22199e64879a9cf1dc112951112 |
| Source note | uspto-grants-2008_07 |