1-(Bromomethyl)-3-(trifluoromethyl)benzene → {3-[1,1-Dioxo-2-(3-trifluoromethyl-benzyl)-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-5-methyl-indol-1-yl}-acetic acid

HRID 750663Notes

Reaction equation

HRID 750663 reaction equation
C([O:5][C:6](=[O:29])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH3:17])=[CH:14][CH:15]=2)[C:10]([CH:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[S:20](=[O:28])(=[O:27])[NH:19]2)=[CH:9]1)(C)(C)C.[F:30][C:31]([F:41])([F:40])[C:32]1[CH:33]=[C:34]([CH:37]=[CH:38][CH:39]=1)[CH2:35]Br>>[O:28]=[S:20]1(=[O:27])[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH:18]([C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=3)[N:8]([CH2:7][C:6]([OH:5])=[O:29])[CH:9]=2)[N:19]1[CH2:35][C:34]1[CH:37]=[CH:38][CH:39]=[C:32]([C:31]([F:30])([F:40])[F:41])[CH:33]=1

Participants

3

Reactant 2

HCID 1230611-(Bromomethyl)-3-(trifluoromethyl)benzeneHCID 67317704[3-(1,1-Dioxo-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl)-5-methyl-indol-1-yl]-acetic acid tert-butyl ester

Product 1

HCID 59753831{3-[1,1-Dioxo-2-(3-trifluoromethyl-benzyl)-2,3-dihydro-1h-1lambda6-benzo[d]isothiazol-3-yl]-5-methyl-indol-1-yl}-acetic acid

Procedure

The title compound was prepared by the method described for example 14 using the product from example 2, step c) and 3-trifluoromethyl benzyl bromide. MS: ESI (negative): 513 (M−H).

Sources & evidence

ORD record
ord-2fb54e691a5c4268acc917550283fbfa
Source dataset
uspto-grants-2008_07
Patent number
US07405215B2

Reaction notes

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