関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,4-Heptanedione, 6-methyl- | HCID 76354 | — |
| 反応物 | 2-Cyanoethanethioamide | HCID 1416277 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178425008 | HCID 178425008 | 61.7% |
反応手順
To a stirred solution of cyanothioacetamide (2.20 g, 22 mmol) and 6-methyl-2,4-heptanedione (3.12 g, 22 mmol) in anhydrous EtOH (40 mL) was added triethylamine (0.4 mL) and the reaction was heated at 50° C. for 1 h before it was allowed to cool to room temperature. Filtration and washing of the precipitates with EtOH gave 6-isobutyl-2-mercapto-4-methylnicotinonitrile as a yellow solid (2.8 g, 61%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07405225B2 |
|---|
| 出典データセット | uspto-grants-2008_07 |
|---|
| ORD ID | ord-30196b6a20b94503b4ddba29fbb1edd1 |
|---|
| 出典メモ | uspto-grants-2008_07 |
|---|
