HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → tert-Butyl 4-(Chlorocarbonyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid | HCID 392871 | — |
| Product | tert-Butyl 4-(Chlorocarbonyl)piperidine-1-carboxylate | HCID 21906247 | — |
Reaction Steps
1-Boc-piperidine-4-carboxylic acid (4.4 g, 19.2 mmol) in oxalyl chloride (50 mL) was heated at reflux for 3 h and then concentrated and dried in vacuo to give the acid chloride, 4-chlorocarbonyl-piperidine-1-carboxylic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405225B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-19b4cb5d59e4432baa3744463f21470b |
| Source note | uspto-grants-2008_07 |