Potassium peroxymonosulphate → HCID 23401026, compound

HRID 750759Notes

Reaction equation

HRID 750759 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([O:13][S:14]([C:17]([F:20])([F:19])[F:18])(=[O:16])=[O:15])=[CH:8][C:9]=2[S:11][CH3:12])[S:4][C:3]=1[C:21](=[O:23])[NH2:22].S([O-])(O[O-])(=O)=[O:25].[K+].[K+]>CO.O>[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([O:13][S:14]([C:17]([F:19])([F:18])[F:20])(=[O:16])=[O:15])=[CH:8][C:9]=2[S:11]([CH3:12])=[O:25])[S:4][C:3]=1[C:21](=[O:23])[NH2:22]

Participants

5

Reactant 2

HCID 10313463Potassium peroxymonosulphateHCID 23401025HCID 23401025, compound

Product 1

HCID 23401026HCID 23401026, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

Trifluoromethanesulfonic acid 3-amino-2-carbamoyl-4-methylsulfanyl-thieno[2,3-b]pyridin-6-yl ester (500 mg, 1.29 mmol) was dissolved in MeOH (10 mL), chilled to 0° C., and potassium peroxymonosulfate (950 mg, 1.55 mmol) dissolved in water (15 mL) was added. The mixture was stirred for 18 h after which it was filtered to give the desired trifluoromethanesulfonic acid 3-amino-2-carbamoyl-4-methanesulfinyl-thieno[2,3-b]pyridin-6-yl ester in 86% yield.

Workup

  1. additionwas added
  2. filtrationwas filtered

Sources & evidence

ORD record
ord-0127ea7627eb4e0686370cdcfc1f4cc5
Source dataset
uspto-grants-2008_07
Patent number
US07405225B2

Reaction notes

Loading…