3-Fluorobenzylic alcohol → HCID 59753910, compound

Participants

Reaction Steps

2-Methylthio-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine (from Reference Example 3) was reacted with 3-fluorobenzyl alcohol according to the procedures described in Example 1 to afford 2-(3-fluorobenzyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine as the higher Rf product.(95/5 hexane/ethyl acetate TLC. HPLC/MS: 460 (M+); Rt=4.66 min; 1H-NMR 500 MHz (CDCl3): δ 5.53 (s, 2H), 7.04 (d over m, J=9 Hz, 3H), 7.2-7.3 (m, 6H), 7.36-7.4 (m, 2H), 8.61 (s, 1H).

Provenance & Evidence