Dimethylamine → HCID 10407323, compound

Participants

Reaction Conditions

Reaction Steps

To a 25 mL thick glass wall pressure tube was added a stirrer bar, 4 mL DMF and 2-methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine (42 mg 0.1 mmol). Then excess dimethylamine in ether (2M) was added, the tube sealed and heated at 100° C. for 18 h. The solvents were removed under high vacuum, and product was obtained. HPLC/MS: m/e=379 (M+1); Rt=3.79 min; 1H-NMR 500 MHz (CDCl3): δ 3.18 (s, 6H), 7.40 (d, J=9 Hz, 1H), 7.5-7.6 (m, 3H), 7.8 (m, 2H), 8.20 (s, 1H).

Provenance & Evidence