2,4-Bis(methylsulfonyl)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine → HCID 10054613, compound

HRID 750807Notes

Reaction equation

HRID 750807 reaction equation
[Na].FC1C=C(C=CC=1F)C[O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[C:11]([F:16])[CH:10]=1.CS([C:25]1[N:30]=[C:29]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][C:32]=2[Cl:38])[C:28]([C:39]2[CH:44]=[CH:43][C:42]([Cl:45])=[CH:41][CH:40]=2)=[C:27](S(C)(=O)=O)[N:26]=1)(=O)=O>>[F:16][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][C:12]=1[F:15])[CH2:8][O:7][C:25]1[N:26]=[C:27]([O:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[C:11]([F:16])[CH:10]=2)[C:28]([C:39]2[CH:44]=[CH:43][C:42]([Cl:45])=[CH:41][CH:40]=2)=[C:29]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][C:32]=2[Cl:38])[N:30]=1

Participants

3

Reactant 2

HCID 597538832,4-Bis(methylsulfonyl)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidineHCID 69199296HCID 69199296, compound

Product 1

HCID 10054613HCID 10054613, compound

Procedure

In Examples 17-19, the procedure described in Example 16 was followed but with substitution of the appropriate sodium alkoxide (2 eq) for sodium-3,4-difluorobenzyloxide in the reaction with 2,4-bis(methylsulfonyl)-5-[4-chlorophenyl]-6-[2,4-dichlorophenyl]pyrimidine (Reference Example 5) to afford the following compounds:

Workup

  1. customto afford the following compounds

Sources & evidence

ORD record
ord-449cea4122274be7bc84b5a76675a159
Source dataset
uspto-grants-2008_07
Patent number
US07405221B2

Reaction notes

Loading…