Acetic Anhydride → HCID 10098195, compound

Participants

Reaction Steps

To a round bottom flask fitted with a magnetic stirrer bar and rubber septum was added 2-(3,4-difluorophenoxy)-4-amino-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (Example 32) (20 mg, 0.04 mmol), 500 μL acetic anhydride and 10 mg of 4-(N,N-dimethylamino)pyridine (DMAP). The mixture was heated at reflux for 10 minutes and then worked up by removing the solvent/reagent under high vacuum. Flash chromatography on silica gel (70/30 hexanes/ethyl acetate) afforded the desired product. 1H-NMR 500 MHz (CDCl3): δ 2.41 (s, 3H), 7.06-7.67(m, 10H), 8.03 (bs, 1H).

Provenance & Evidence