Acetic Anhydride → 2-(3,4-Difluorobenzyloxy)-4-(acetylamino)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-pyrimidine

Participants

Reaction Steps

The title compound was obtained by treating 2-(3,4-difluorobenzyloxy)-4-amino-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (Example 33) with acetic anhydride and catalytic DMAP by the same general procedure described in Example 34. Workup and flash column chromatography on silica gel (eluted with 80/20 hexanes/ethyl acetate) afforded the desired product. HPLC/MS: m/e=536 (M++1); Rt=4.5 min. 1H-NMR 500 MHz (CDCl3): δ 2.56 (s, 3H), 5.45 (s, 2H), 7.03-7.27 (m, 9H), 7.38 (d, J=2 Hz, 1H), 8.05 (bs, 1H).

Provenance & Evidence