Pyrrolidine → HCID 10325170, compound

Participants

Reaction Steps

2-(Methylsulfonyl)-4-(3,4-difluorobenzyloxy)-5-[4-chlorophenyl]-6-[2,4-dichlorophenyl]pyrimidine (Reference Example 6, 55 mg, 0.10 mmol) was reacted in excess neat pyrrolidine at 80° C. overnight by the general procedure described in Example 31, Step A. Workup (solvent removal under reduced pressure) and flash column chromatography on silica gel (eluted with 92/8 hexanes/ethyl acetate) afforded the title compound. HPLC/MS: m/e=548 (M++1); Rt=4.76 min. 1H-NMR 500 MHz (CDCl3): δ 2.02 (bs, J=4H), 3.63 (bs, 4H), 5.40 (s, 2H), 7.04 (d, J=8 Hz, 2H), 7.08-7.20 (m, 7H), 7.34 (d, J=2 Hz, 1H).

Provenance & Evidence