Piperidine → HCID 10257243, compound

Participants

Reaction Steps

2-(Methylsulfonyl)-4-(3,4-difluorobenzyloxy)-5-[4-chlorophenyl]-6-[2,4-dichlorophenyl]pyrimidine (Reference Example 6, 48 mg, 0.085 mmol) was reacted in excess neat piperidine at 80° C. overnight by the general procedure described in Example 31, Step A. Workup (solvent removal under reduced pressure, then toluene azeotrope) and flash column chromatography on silica gel (eluted with 90/10 hexanes/ethyl acetate) afforded the title compound. HPLC Rt=5.36 min. 1H-NMR 500 MHz (CDCl3): δ 1.63 (m, 4H), 1.71 (m, 2H), (bs, 4H), 3.83 (m, 4H), 5.36 (s, 2), 7.02 (d, J=8 Hz, 2H), 7.08-7.20 (m, 7H), 7.31(d, J=1 Hz, 1H).

Provenance & Evidence