Cyclohexanol → HCID 69199838, compound

Participants

Reaction Steps

2,4-Bis(methylsulfonyl)-5-[4-chlorophenyl]-6-[2,4-dichlorophenyl]pyrimidine (Reference Example 5) (196 mg, 0.4 mmol) was reacted with 1 equivalent each of n-butyl lithium and cyclohexanol by the procedure described in Reference Examples 6 and 7. Workup and flash column chromatography on silica gel (eluted with 90/10 hexanes/ethyl acetate) afforded 2-cyclohexyloxy-4-(methylsulfonyl)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (Higher Rf product): 1H-NMR 500 MHz (CDCl3): δ 1.30 (m, 5H), 1.45 (m, 1H), 1.55 (m, 1H), 1.64 (m, 1H), 1.75 (m, 1H), 1.90 (m, 1H), 2.15 (m, 1H), 3.38 (s, 3H), 5.09 (m, 1H), 7.0 (d, J=7 Hz, 1H), 7.18-7.22 (m, 4H), 7.36 (d over m, J=2 Hz, 2H); and 2-methylsulfonyl-4-cyclohexyl-oxy-5-(4chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (Lower Rf product): 1H-NMR 500 MHz (CDCl3): δ 0.87-0.9 (m, 1H), 0.95-1.07 (m, 2H), 1.1-1.3 (m, 2H), 1.33 (m, 2H), 1.7-1.82 (m, 4H), 3.40 (s, 3H), 4.37 (d, J=6 Hz, 2H), 7.08 (d, J=8 Hz, 2H), 7.12 (d, J=8 Hz, 1H), 7.22-7.30 (m, 3H), 7.37 (d, J=2 Hz, 1H).

Provenance & Evidence