HCID 57562221, compound → 6-Methacryloyloxy-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-7-carboxylic Acid

HRID 75083Notes

Reaction equation

[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:23])[CH:14]3[CH:15]([C:16]([O:18]C(C)(C)C)=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3]>C(O)=O>[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:23])[CH:14]3[CH:15]([C:16]([OH:18])=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3]

Participants

Conditions

Temperature: 25 °C

Procedure

Dissolved into 810 g of formic acid was 202.2 g of the methacrylate ester (25) obtained in Synthesis Example 1-1-1; and then, the resulting mixture was stirred at 25° C. for 16 hours. After formic acid was removed by distillation under reduced pressure, recrystallization was made from ethyl acetate to give 135.1 g of the intended product (Yield 81%).

Workup

customobtained in Synthesis Example 1-1-1
customAfter formic acid was removed by distillation under reduced pressure, recrystallization

Sources & evidence

ORD record: ord-6bf78c93a04b46a1b0358768fcbcdd68
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08835097B2

Reaction notes

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