3-Pyridinemethanol → 2-(3-Pyridylmethoxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

Participants

Reaction Steps

2-Methylthio-5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)pyrimidine from Reference Example 3 was reacted with 3-pyridinemethanol according to the procedure described in Example 59 to afford 2-(3-pyridylmethoxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine (HRf): HPLC/MS: m/e=442 (M++1); Rt=3.01 min; 1H-NMR 500 MHz (CDCl3): δ 5.61 (s, 2H), 7.05 (d, J=9 Hz, 2H), 7.15-7.22 (m, 1H), 7.24-7.32 (m, 4H), 7.50-7.58 (m, 1H), 7.60 (m, 1H), 7.62-7.63 (m, 1H), 8.45 (m, 1H), 8.83 (s, 1H).

Provenance & Evidence